The H63D variant in the HFE gene predisposes to arthralgia, chondrocalcinosis and osteoarthritis

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The H63D variant in the HFE gene predisposes to arthralgia, chondrocalcinosis and osteoarthritis.

OBJECTIVES To investigate the relation between the HFE C282Y and H63D variants with arthralgia and joint pathology in the population-based Rotterdam Study. METHODS From a cohort of 7983 people aged 55 years and over, 2095 randomly drawn subjects were genotyped for C282Y and H63D variants. We compared the frequency of arthralgia, and the presence of chondrocalcinosis, osteophytes, joint space ...

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ژورنال

عنوان ژورنال: Annals of the Rheumatic Diseases

سال: 2007

ISSN: 0003-4967

DOI: 10.1136/ard.2006.063099